Hydroxyamine hydrochloride → HCID 72327488, 화합물

HRID 2381230노트

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HRID 2381230 반응식
[CH2:1]([O:8][C:9]1[C:16]([O:17][CH3:18])=[CH:15][C:12]([CH:13]=O)=[C:11]([I:19])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[NH2:21][OH:22].C([O-])(=O)C.[Na+]>C(O)C>[CH2:1]([O:8][C:9]1[C:16]([O:17][CH3:18])=[CH:15][C:12]([CH:13]=[N:21][OH:22])=[C:11]([I:19])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 127730874-Benzyloxy-2-iodo-5-methoxybenzaldehyde

생성물 1

HCID 72327488HCID 72327488, 화합물수율 100.8%

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
70 °C

실험 절차

A mixture of 4-benzyloxy-2-iodo-5-methoxybenzaldehyde (reference example 1-1) (12.2 g), hydroxylamine hydrochloride (2.54 g), sodium acetate (6 g) and ethanol (170 mL) was stirred at 70° C. for 1.5 hours. The mixture was concentrated under reduced pressure. Water was added to the residue, and the mixture was stirred at room temperature for 30 minutes. The solid was collected by filtration to give the title compound (12.8 g).

후처리

  1. concentrationThe mixture was concentrated under reduced pressure
  2. additionWater was added to the residue
  3. stirringthe mixture was stirred at room temperature for 30 minutes
  4. filtrationThe solid was collected by filtration

출처 및 근거

ORD 기록
ord-4a6b0e73ca764d3084bb456a139caf2f
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08258162B2

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