Pyridine → 1-(2,4-Dichlorophenyl)-propan-2-one oxime
반응식
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH2:9][C:10](=O)[CH3:11].Cl.[NH2:14][OH:15].N1C=CC=CC=1>CO>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH2:9][C:10](=[N:14][OH:15])[CH3:11]참가 물질
5
실험 절차
A solution of 1-(2,4-dichlorophenyl)-propan-2-one (3.46 g, 16.7 mmole) in methanol (40 ml) was treated with hydroxylamine hydrochloride (1.40 g, 20.6 mmol) followed by pyridine (1.7 ml, 20.6 mmol). The resulting mixture was stirred at ambient temperature over night for 16 hours. The reaction mixture was poured onto water (200 ml). The solid product was collected by filtration, washed with water and dried (40° C., 100 mbar). 3.63 g (100% of theory) of 1-(2,4-dichlorophenyl)-propan-2-one oxime was obtained in form of a white solid (m.p. 120-124° C.).
후처리
- additionThe reaction mixture was poured onto water (200 ml)
- filtrationThe solid product was collected by filtration
- washwashed with water
- customdried (40° C., 100 mbar)
출처 및 근거
- ORD 기록
- ord-c439a8191fa3444a9c6465158443decf
- 출처 데이터셋
- uspto-grants-2012_09
- 특허 번호
- US08258169B2
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