Chlorotrimethylsilane → N4-(3-amino-2,2-dimethylpropyl)-N2-(1H-indazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine

HRID 2381664노트

반응식

HRID 2381664 반응식
[NH2:1][CH2:2][C:3]([CH3:17])([CH3:16])[CH2:4][NH:5][C:6]1[C:7]2[CH:15]=[CH:14][NH:13][C:8]=2[N:9]=[C:10](Cl)[N:11]=1.[NH2:18][C:19]1[CH:27]=[C:26]2[C:22]([CH:23]=[N:24][NH:25]2)=[CH:21][CH:20]=1.C[Si](Cl)(C)C>C(O)CCC>[NH2:1][CH2:2][C:3]([CH3:17])([CH3:16])[CH2:4][NH:5][C:6]1[C:7]2[CH:15]=[CH:14][NH:13][C:8]=2[N:9]=[C:10]([NH:18][C:19]2[CH:27]=[C:26]3[C:22]([CH:23]=[N:24][NH:25]3)=[CH:21][CH:20]=2)[N:11]=1

참가 물질

5

반응물 3

HCID 6397ChlorotrimethylsilaneHCID 814231H-Indazol-6-amineHCID 86636615N-(3-amino-2,2-dimethylpropyl)-2-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-amine

생성물 1

HCID 44467882N4-(3-amino-2,2-dimethylpropyl)-N2-(1H-indazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine수율 15.3%

시약·촉매·용매 1

HCID 2631-Butanol용매

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온도
116 °C

실험 절차

A mixture of N-(3-amino-2,2-dimethylpropyl)-2-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-amine (70 mg, 0.28 mmol), 6-aminoindazole (93 mg, 0.70 mmol) and trimethylsilyl chloride (0.100 mL, 0.72 mmol) in nBuOH (2 mL) was heated at 116° C. overnight. It was then purified by HPLC to give the titled compound (15 mg). MS 351.4 (M+H); UV 206.1, 242.6, 304.3 nm.

후처리

  1. customIt was then purified by HPLC

출처 및 근거

ORD 기록
ord-61b0b270e8cb4fbbb429966a16f479c0
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08258144B2

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