Hydrochloric Acid → Methyl[1-(3-aminopropyl)cyclopropyl]acetate hydrochloride
반응식
[CH3:1][O:2][C:3](=[O:14])[CH2:4][C:5]1([CH2:8][CH2:9][CH2:10][N:11]=[N+]=[N-])[CH2:7][CH2:6]1.[ClH:15]>[Pd].C(O)C>[ClH:15].[CH3:1][O:2][C:3](=[O:14])[CH2:4][C:5]1([CH2:8][CH2:9][CH2:10][NH2:11])[CH2:6][CH2:7]1참가 물질
5
실험 절차
At room temperature, a mixture of 389 mg (1.97 mmol) of methyl[1-(3-azidopropyl)cyclopropyl]acetate, 40 mg of 10% palladium on carbon and 1.97 ml (1.97 mmol) of 1 M hydrochloric acid in 10 ml of ethanol were hydrogenated under atmospheric pressure overnight. After the reaction had ended, the mixture was filtered and the filtrate was concentrated to dryness. This gave 313 mg (1.51 mmol, 76% of theory) of the title compound as a colorless oil.
후처리
- customwere hydrogenated under atmospheric pressure overnight
- filtrationthe mixture was filtered
- concentrationthe filtrate was concentrated to dryness
출처 및 근거
- ORD 기록
- ord-77f1075bbca04348a8b55fa5af00fd99
- 출처 데이터셋
- uspto-grants-2014_02
- 특허 번호
- US08642592B2
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