Chlorotrimethylsilane → N2-(1H-indazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2,4-diamine

HRID 2381704노트

반응식

HRID 2381704 반응식
Cl[C:2]1[N:3]=[C:4]([NH2:11])[C:5]2[CH:10]=[CH:9][NH:8][C:6]=2[N:7]=1.[NH2:12][C:13]1[CH:21]=[C:20]2[C:16]([CH:17]=[N:18][NH:19]2)=[CH:15][CH:14]=1.C[Si](Cl)(C)C>C(O)CCC>[NH:19]1[C:20]2[C:16](=[CH:15][CH:14]=[C:13]([NH:12][C:2]3[N:3]=[C:4]([NH2:11])[C:5]4[CH:10]=[CH:9][NH:8][C:6]=4[N:7]=3)[CH:21]=2)[CH:17]=[N:18]1

참가 물질

5

반응물 3

HCID 6397ChlorotrimethylsilaneHCID 814231H-Indazol-6-amineHCID 598923042-Chloro-7H-pyrrolo[2,3-d]pyrimidin-4-amine

생성물 1

HCID 44467884N2-(1H-indazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2,4-diamine수율 12.8%

시약·촉매·용매 1

HCID 2631-Butanol용매

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온도
115 °C

실험 절차

To a mixture of 2-chloro-7H-pyrrolo[2,3-d]pyrimidine-4-amine (0.06 g, 0.353 mmol) in nBuOH (0.7 mL) was added 6-aminoindazole (0.094 g, 0.70 mmol) and TMSCl (0.023 mL, 0.175 mmol). After heating at 115° C. for 8 h, it was cooled and purified by prep HPLC to give N2-(1H-indazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2,4-diamine (0.012 g, MS calcd for C13H11N7 265.3, found 266.1; UV 216.9, 308.0 nm).

후처리

  1. temperatureit was cooled
  2. custompurified by prep HPLC

출처 및 근거

ORD 기록
ord-cef5f86ba1b84604b6d4db05d6ef202c
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08258144B2

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