Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Aminoimidazole-4-carboxamide → Temozolomide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Aminoimidazole-4-carboxamide | HCID 9679 | — |
| 반응물 | Methyl Isocyanate | HCID 12228 | — |
| 반응물 | 5-diazo-1H-imidazole-4-carboxamide | HCID 136377446 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Temozolomide | HCID 5394 | — |
반응 단계
Med. Chem. 1984, 27, 196-201 describes a process wherein 5-amino-1H-imidazole-4-carboxamide is converted into 5-diazo-1H-imidazole-4-carboxamide, which is then cyclised with methylisocyanate in dichloromethane to provide a high yield of temozolomide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08258294B2 |
| 출처 데이터셋 | uspto-grants-2012_09 |
| ORD ID | ord-921888acf71f4518ac900a0a05f2b570 |
| 출처 메모 | uspto-grants-2012_09 |