Pyridine → HCID 62909796, 화합물

HRID 2382608노트

반응식

HRID 2382608 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:9])=[C:6]([CH:8]=1)[NH2:7].[C:10]1([S:16](Cl)(=[O:18])=[O:17])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.N1C=CC=CC=1.CCOC(C)=O>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:9])=[C:6]([NH:7][S:16]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)(=[O:18])=[O:17])[CH:8]=1

참가 물질

6

반응물 4

HCID 1049PyridineHCID 7369Benzenesulfonyl chlorideHCID 8857Ethyl AcetateHCID 38307312-Chloro-5-bromoaniline

생성물 1

HCID 62909796HCID 62909796, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a stirring solution of 5-Bromo-2-chloroaniline (100 mg, 0.48 mmol) in DCM (5 ml) is added benzenesulfonyl chloride (280 mg, 202 ul, 1.58 mmol) and pyridine (195 ul, 2.42 mmol). The reaction mixture is stirred at room temperature for 18 hours. EtOAc (20 ml) is added and the reaction mixture is washed with 0.1 m HCl (20 ml), the phases are separated and the organic portion is washed with water (3×), dried over MgSO4, concentrated in vacuo and dried in a vacuum oven to afford the title compound.

후처리

  1. washthe reaction mixture is washed with 0.1 m HCl (20 ml)
  2. customthe phases are separated
  3. washthe organic portion is washed with water (3×)
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated in vacuo
  6. customdried in a vacuum oven

출처 및 근거

ORD 기록
ord-8ecb7044d6da4a6582e70e5b9ba65665
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08263585B2

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