Sodium Hydroxide → HCID 58110193, 화합물

HRID 238278

반응식

HRID 238278 반응식
C[O:2][C:3]([C:5]1[CH:9]=[C:8]([C:10]2[CH:11]=[N:12][NH:13][CH:14]=2)[S:7][CH:6]=1)=[O:4].[OH-].[Na+]>CO>[NH:12]1[CH:11]=[C:10]([C:8]2[S:7][CH:6]=[C:5]([C:3]([OH:4])=[O:2])[CH:9]=2)[CH:14]=[N:13]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 58110358methyl 5-(1H-pyrazol-4-yl)thiophene-3-carboxylate

생성물 1

HCID 58110193HCID 58110193, 화합물수율 68.5%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

5-(1H-Pyrazol-4-yl)-thiophene-3-carboxylic acid methyl ester (2.8 g, 13.3 mmol) was dissolved in a mixture of methanol (18 mL) and a solution of aqueous sodium hydroxide (1 N, 18 mL) and the mixture stirred at 50° C. for 1.5 hours. The mixture was concentrated under vacuum and acidified with aqueous hydrochloric acid (1N). The resulting precipitate was isolated by filtration and washed with water before drying under vacuum to give the title compound as a white solid (1.77 g). LCMS m/z 195.1 [M+H]+. R.T.=3.23 min (Analytical Method 4). 1H NMR (400 MHz, d6-DMSO): δ 8.1 (s, 1H), 8.0 (m, 2H), 7.45 (s, 1H).

후처리

  1. concentrationThe mixture was concentrated under vacuum
  2. customThe resulting precipitate was isolated by filtration
  3. washwashed with water
  4. custombefore drying under vacuum

출처 및 근거

ORD 기록
ord-f0015b981396470ca9ca90688886efa0
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08642621B2

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