p-Anisoyl chloride → N-[5-(3-furyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-4-methoxybenzamide

HRID 2382806노트

반응식

HRID 2382806 반응식
[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[N:11]3[N:12]=[C:13]([NH2:15])[N:14]=[C:10]3[CH:9]=[CH:8][CH:7]=2)=[CH:2]1.[C:16](Cl)(=[O:25])[C:17]1[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=1>>[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[N:11]3[N:12]=[C:13]([NH:15][C:16](=[O:25])[C:17]4[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=4)[N:14]=[C:10]3[CH:9]=[CH:8][CH:7]=2)=[CH:2]1

참가 물질

3

반응물 2

HCID 7477p-Anisoyl chlorideHCID 252159385-(Furan-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine

생성물 1

HCID 25213271N-[5-(3-furyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-4-methoxybenzamide

실험 절차

The title compound was prepared following procedure and work up described for example 19, but starting from 5-(3-furyl)[1,2,4]triazolo[1,5-a]pyridin-2-amine ((A2), 50 mg; 0.25 mmol; 1.0 eq.) and p-anisoyl chloride (66 mg; 0.50 mmol; 2.0 eq.) as a white powder (58.2 mg, 69%). HPLC, Rt: 3.19 min. (purity 97.0%).

출처 및 근거

ORD 기록
ord-752c119e141448d2a8d7ee9b2d9e4dcb
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08263595B2

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