HCID 67059991, 화합물 → 4-(2-Chlorophenyl)piperidine hydrochloride

HRID 238283노트

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HRID 238283 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:13][CH2:12][N:11](C(=O)C)[CH2:10][CH2:9]1>[OH-].[Na+].C(O)C>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1

참가 물질

4

반응물 1

HCID 67059991HCID 67059991, 화합물

생성물 1

HCID 219369514-(2-Chlorophenyl)piperidine hydrochloride수율 122.9%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 14798Sodium Hydroxide용매

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온도
50 °C

실험 절차

1-[4-(2-Chloro-phenyl)-piperidin-1-yl]-ethanone (0.2 g) was dissolved in a solution of aqueous sodium hydroxide (1 N, 5 mL) and ethanol (10 mL) and heated to 50° C. for 6 hours. The solvent was removed by evaporation under vacuum, and the products extracted into ethyl acetate, washed with water (20 mL) then dried over magnesium sulphate, filtered and the solvent removed by evaporation under vacuum. The residue was dissolved in a solution of hydrogen chloride in dioxane (4 N, 1 mL) and the solvent evaported to give the title compound as a pale yellow solid (0.12 g). LCMS m/z 196.1 [M+H]+. R.T.=2.46 min (Analytical Method 4).

후처리

  1. customThe solvent was removed by evaporation under vacuum
  2. extractionthe products extracted into ethyl acetate
  3. washwashed with water (20 mL)
  4. dry with materialthen dried over magnesium sulphate
  5. filtrationfiltered
  6. customthe solvent removed by evaporation under vacuum
  7. dissolutionThe residue was dissolved in a solution of hydrogen chloride in dioxane (4 N, 1 mL)

출처 및 근거

ORD 기록
ord-584ad0baa6964a0190a1c5a728750e8c
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08642621B2

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