Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Guanidine Hydrochloride → 2-Amino-6-(4-methoxydibenzo[b,d]furan-1-yl)-4-oxo-3,4,5,6,7,8-hexahydroquinazoline-6-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Guanidine Hydrochloride | HCID 5742 | — |
| 반응물 | Sodium Methoxide | HCID 10942334 | — |
| 반응물 | 5-Cyano-5-(4-methoxy-dibenzofuran-1-yl)-2-oxo-cyclohexane carboxylic acid methyl ester | HCID 24755595 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 2-Amino-6-(4-methoxydibenzo[b,d]furan-1-yl)-4-oxo-3,4,5,6,7,8-hexahydroquinazoline-6-carbonitrile | HCID 135620490 | — |
반응 단계
A mixture of the compound obtained in example 1 (200 mg, 0.53 mmol), guanidine HCl (127 mg, 1.326 mmol) and sodium methoxide (100 mg) in 2 ml methanol was stirred overnight at room temperature. The solvent was evaporated under vacuum and the crude residue was purified by column chromatography to get 150 mg (73.3% yields) as a white solid product. MP-decomposes at 300° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08263648B2 |
| 출처 데이터셋 | uspto-grants-2012_09 |
| ORD ID | ord-5118ad178b0a4837bf9e7e93f162879a |
| 출처 메모 | uspto-grants-2012_09 |