反应详情

A mixture of the compound obtained in example 1 (200 mg, 0.53 mmol), guanidine HCl (127 mg, 1.326 mmol) and sodium methoxide (100 mg) in 2 ml methanol was stirred overnight at room temperature. The solvent was evaporated under vacuum and the crude residue was purified by column chromatography to get 150 mg (73.3% yields) as a white solid product. MP-decomposes at 300° C.

1. customThe solvent was evaporated under vacuum
2. customthe crude residue was purified by column chromatography
3. customto get
4. custom150 mg (73.3% yields) as a white solid product
5. customat 300° C.