N-bromobutanimide → 2-Bromo-4,4-dimethyl-3-oxopentanenitrile

HRID 2384465노트

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HRID 2384465 반응식
[C:1]([CH2:7][C:8]#[N:9])(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3].[Br:10]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl>[Br:10][CH:7]([C:1](=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3])[C:8]#[N:9]

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 108871Pentanenitrile, 4,4-dimethyl-3-oxo-

생성물 1

HCID 115864832-Bromo-4,4-dimethyl-3-oxopentanenitrile수율 87.9%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

Pivaloylacetonitrile (1.00 g, 7.99 mmol) was dissolved in carbon tetrachloride (15 mL). N-Bromosuccinimide (1.42 g, 7.99 mmol) was added, and the mixture was refluxed for 15 minutes. After cooling, the insoluble matter was filtered off, and the residue obtained by evaporation of the filtrate under reduced pressure was purified by chromatography on silica gel (n-hexane:ethyl acetate=4:1) to give the title compound (1.43 g, 87.9%) as a yellowish brown oil.

후처리

  1. temperaturethe mixture was refluxed for 15 minutes
  2. temperatureAfter cooling
  3. filtrationthe insoluble matter was filtered off
  4. customthe residue obtained by evaporation of the filtrate under reduced pressure
  5. customwas purified by chromatography on silica gel (n-hexane:ethyl acetate=4:1)

출처 및 근거

ORD 기록
ord-9fac9ba62bf54ebbbec92822c636fda5
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08263657B2

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