Hydrochloric Acid → 6-[4-(Azetidin-3-yloxy)-3-methoxy-phenyl]-2-(4-chloro-phenyl)-5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one hydrochloride

HRID 2384908노트

반응식

HRID 2384908 반응식
[NH:1]1[CH2:4][CH:3]([O:5][C:6]2[CH:11]=[CH:10][C:9]([N:12]3[CH2:17][CH2:16][C:15]4[CH:18]=[C:19]([C:21]5[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=5)[S:20][C:14]=4[C:13]3=[O:28])=[CH:8][C:7]=2[O:29][CH3:30])[CH2:2]1.Cl>C(Cl)Cl.C(O)C>[ClH:27].[NH:1]1[CH2:2][CH:3]([O:5][C:6]2[CH:11]=[CH:10][C:9]([N:12]3[CH2:17][CH2:16][C:15]4[CH:18]=[C:19]([C:21]5[CH:22]=[CH:23][C:24]([Cl:27])=[CH:25][CH:26]=5)[S:20][C:14]=4[C:13]3=[O:28])=[CH:8][C:7]=2[O:29][CH3:30])[CH2:4]1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 689510906-[4-(azetidin-3-yloxy)-3-methoxy-phenyl]-2-(4-chloro-phenyl)-5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one

생성물 1

HCID 689510896-[4-(Azetidin-3-yloxy)-3-methoxy-phenyl]-2-(4-chloro-phenyl)-5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one hydrochloride

시약·촉매·용매 2

HCID 702Ethanol용매HCID 6344Dichloromethane용매

실험 절차

Prepare the HCl salt by dissolving the residue in CH2Cl2 and adding HCl in ethanol. Add ether to the mixture then filter and dry the solid to obtain the title compound. LC-MS/ES m/z (35Cl) 441.0 [M+H]+.

후처리

  1. filtrationAdd ether to the mixture then filter
  2. customdry the solid

출처 및 근거

ORD 기록
ord-9b44716eb4e94ac98a92731479aba650
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08263772B2

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