5-Aminopentan-1-ol → N-(5-hydroxypentyl)-3-(N-vinylformamido)propionamide
반응식
[CH:1]([N:3]([CH2:6][CH2:7][C:8]([O:10]C)=O)[CH:4]=[O:5])=[CH2:2].[NH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][OH:18].C[O-].[Na+]>CO>[OH:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][NH:12][C:8](=[O:10])[CH2:7][CH2:6][N:3]([CH:1]=[CH2:2])[CH:4]=[O:5]참가 물질
5
실험 절차
The apparatus of Example 2 was charged with 15.7 grams (0.1 mol) of methyl 3-(N-vinylformamido)propionate, 10.3 grams (0.1 mol) of 5-amino-1-pentanol and 0.12 gram of 25% sodium methoxide in methanol solution. The mixture was stirred at 90° C. for 3 hours after which the methanol coproduct was removed by distillation at reduced pressure. NMR analysis of the remaining amber liquid indicated about 69% conversion to the desired product.
후처리
- customwas removed by distillation at reduced pressure
출처 및 근거
- ORD 기록
- ord-575fdaab9b024e09a2ac34fb099e5fd0
- 출처 데이터셋
- uspto-grants-1998_03
- 특허 번호
- US05728878
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