Hydrochloric Acid → 3,3-Dimethyl-6-nitroindoline
반응식
[CH3:1][C:2]1([CH3:17])[C:10]2[C:5](=[CH:6][C:7]([N+:11]([O-:13])=[O:12])=[CH:8][CH:9]=2)[N:4](C(=O)C)[CH2:3]1.Cl>CCO>[CH3:1][C:2]1([CH3:17])[C:10]2[C:5](=[CH:6][C:7]([N+:11]([O-:13])=[O:12])=[CH:8][CH:9]=2)[NH:4][CH2:3]1참가 물질
4
반응 조건
- 온도
- 70 °C
실험 절차
1-(3,3-Dimethyl-6-nitro-2,3-dihydro-indol-1-yl)ethanone (1.8 g, Step C) was dissolved in EtOH (50 mL), 12N HCl (50 mL) was added and the resulting mixture was heated at 70° C. overnight. After the mixture was concentrated in vacuo, it was partitioned between saturated NaHCO3 solution and EtOAc, the resulting organic layer was dried over MgSO4, filtered and concentrated in vacuo to afford a yellow solid. MS: 193 (M+1). Calc'd. for C10H12N2O2—192.21.
후처리
- concentrationAfter the mixture was concentrated in vacuo, it
- customwas partitioned between saturated NaHCO3 solution and EtOAc
- dry with materialthe resulting organic layer was dried over MgSO4
- filtrationfiltered
- concentrationconcentrated in vacuo
- customto afford a yellow solid
출처 및 근거
- ORD 기록
- ord-fb5c69e5fa60499cb5685b37998bf572
- 출처 데이터셋
- uspto-grants-2014_02
- 특허 번호
- US08642624B2
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