Thionyl Chloride → 2-Fluoropyridine-3-carbonyl chloride

반응식

[F:1][C:2]1[C:7]([C:8]([OH:10])=O)=[CH:6][CH:5]=[CH:4][N:3]=1.O=S(Cl)[Cl:13]>>[F:1][C:2]1[C:7]([C:8]([Cl:13])=[O:10])=[CH:6][CH:5]=[CH:4][N:3]=1

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 960892-Fluoronicotinic acid

생성물 1

HCID 219595822-Fluoropyridine-3-carbonyl chloride

실험 절차

2-Fluoropyridine-3-carboxylic acid (7 g, Step C) was suspended in SOCl2 (100 mL). After heating under reflux for 2 h, the mixture became homogeneous. Excess SOCl2 was removed in vacuo to afford a brown solid as desired product.

후처리

temperatureAfter heating
temperatureunder reflux for 2 h
customExcess SOCl2 was removed in vacuo

출처 및 근거

ORD 기록: ord-9a43b48ccf53428fb07ec0624f068c33
출처 데이터셋: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08642624B2

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