Hydrochloric Acid → HCID 178477659, 화합물

HRID 238583노트

반응식

HRID 238583 반응식
[OH-].[K+].C(S([C:8]1[CH:13]=[CH:12][C:11]([S:14]([CH2:17][CH3:18])(=[O:16])=[O:15])=[CH:10][N:9]=1)(=O)=O)C.[O:19]1CCCC1.Cl>O>[CH2:17]([S:14]([C:11]1[CH:12]=[CH:13][C:8]([OH:19])=[N:9][CH:10]=1)(=[O:16])=[O:15])[CH3:18]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 14797Potassium HydroxideHCID 132780152,5-Bis(ethylsulfonyl)pyridine

생성물 1

HCID 178477659HCID 178477659, 화합물

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

A solution of potassium hydroxide (11.0 g, 196 mmol, 50%) in water was added to a suspension of 2,5-bis-ethanesulfonyl-pyridine (12.0 g, 45.6 mmol, prepared using the method described above) in water and tetrahydrofuran (100 mL, 1:1, v/v). After being heated at reflux for 1 hour, the mixture was acidified with 0.5 N hydrochloric acid to pH 3 and concentrated in vacuo to remove the solvent. The residue was triturated with boiling ethanol (150 mL) and filtered. The filtrates were concentrated in vacuo to afford the crude product which was used in the next step without further purification.

후처리

  1. customprepared
  2. temperatureAfter being heated
  3. temperatureat reflux for 1 hour
  4. concentrationconcentrated in vacuo
  5. customto remove the solvent
  6. customThe residue was triturated with boiling ethanol (150 mL)
  7. filtrationfiltered
  8. concentrationThe filtrates were concentrated in vacuo

출처 및 근거

ORD 기록
ord-f2ecad1a18ee4e4e9b16ee032d053956
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08642629B2

반응 노트

불러오는 중…