Hydrochloric Acid → HCID 59326505, 화합물

HRID 238594노트

반응식

HRID 238594 반응식
[CH3:1][O:2][C:3]([C:5]1[CH:14]=[C:13]([O:15]C(=O)C)[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([F:19])[CH:11]=2)[CH:6]=1)=[O:4].C[O-].[Na+].Cl>CO>[CH3:1][O:2][C:3]([C:5]1[CH:14]=[C:13]([OH:15])[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([F:19])[CH:11]=2)[CH:6]=1)=[O:4]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 10942334Sodium MethoxideHCID 593266124-Acetoxy-6-fluoro-naphthalene-2-carboxylic acid methyl ester

생성물 1

HCID 59326505HCID 59326505, 화합물수율 107.6%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 4-acetoxy-6-fluoro-naphthalene-2-carboxylic acid methyl ester (1 g, 3.8 mmol) in methanol (20 mL) was added sodium methoxide (309 mg, 5.7 mmol). After being stirred at room temperature for 1 hour, the reaction mixture was acidified with 1 N hydrochloric acid to pH 3. The resulting precipitate was collected by filtration and dissolved in ethyl acetate. The organic solution was dried over sodium sulfate, and concentrated in vacuo to afford 900 mg of crude 6-fluoro-4-hydroxy-naphthalene-2-carboxylic acid methyl ester as a pale yellow solid, which was used in the next step without further purification.

후처리

  1. filtrationThe resulting precipitate was collected by filtration
  2. dissolutiondissolved in ethyl acetate
  3. dry with materialThe organic solution was dried over sodium sulfate
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-6d47b1d7177043cd92e29110a7a58cf5
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08642629B2

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