Ethylene Glycol → 2-hydroxyethyl 3-(N-vinylformamido)propionate

HRID 2386

반응식

HRID 2386 반응식
[CH:1]([N:3]([CH2:6][CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH:4]=[O:5])=[CH2:2].C(O)C[OH:15].C[O-].[Na+].C(O)C>CO>[CH:1]([N:3]([CH2:6][CH2:7][C:8]([O:10][CH2:11][CH2:12][OH:15])=[O:9])[CH:4]=[O:5])=[CH2:2]

참가 물질

6

반응물 4

HCID 174Ethylene GlycolHCID 702EthanolHCID 10942334Sodium MethoxideHCID 19690337ethyl 3-(N-vinylformamido)propionate

생성물 1

HCID 196903422-hydroxyethyl 3-(N-vinylformamido)propionate

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
90 °C

실험 절차

The apparatus of Example 2 was charged with 17.1 grams (0.1 mol) of ethyl 3-(N-vinylformamido)propionate, 6.2 grams (0.1 mol) of ethylene glycol, and 0.15 gram of 25% sodium methoxide in methanol solution. The mixture was stirred at 90° C. for 2 hours. No evolution of ethanol was observed during the reaction period. Heating for an additional hour at 135° C. also failed to generate a volatile coproduct which indicated no conversion to the desired product.

후처리

  1. temperatureHeating for an additional hour at 135° C.

출처 및 근거

ORD 기록
ord-9263fd3c38db4e7d8af1acf74087dcb3
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05728878

연결된 노트

불러오는 중…