Benzoyl chloride → (3-Benzoylamino-propyl)-carbamic acid tert-butyl ester

HRID 2386404노트

반응식

HRID 2386404 반응식
[C:1]([O:5][C:6](=[O:12])[NH:7][CH2:8][CH2:9][CH2:10][NH2:11])([CH3:4])([CH3:3])[CH3:2].[C:13](Cl)(=[O:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C(N(CC)CC)C>C(Cl)Cl>[C:1]([O:5][C:6](=[O:12])[NH:7][CH2:8][CH2:9][CH2:10][NH:11][C:13](=[O:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

5

반응물 3

HCID 7412Benzoyl chlorideHCID 8471TriethylamineHCID 2735700tert-Butyl (3-aminopropyl)carbamate

생성물 1

HCID 10492863(3-Benzoylamino-propyl)-carbamic acid tert-butyl ester

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

(3-Amino-propyl)-carbamic acid tert-butyl ester (1.6 g) was treated with benzoyl chloride (1.1 eq.) and triethylamine (1.5 eq) in methylene chloride (50 mL). The reaction mixture was washed with 1 N HCl, sat, NaHCO3, and sat NaCl and the solvent removed to give product. LC-MS showed the product had the expected M+H+ of 279.

후처리

  1. washThe reaction mixture was washed with 1 N HCl
  2. customthe solvent removed
  3. customto give product

출처 및 근거

ORD 기록
ord-dd27532696644c2181c9445e2b220bfc
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08268822B2

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