2-(3-Fluoro-4-methoxyphenyl)ethanamine → 4-(2-Aminoethyl)-2-fluorophenol

HRID 2386462노트

반응식

HRID 2386462 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH2:10][CH2:11][NH2:12])[CH:5]=[CH:6][C:7]=1[O:8]C>Br>[NH2:12][CH2:11][CH2:10][C:4]1[CH:5]=[CH:6][C:7]([OH:8])=[C:2]([F:1])[CH:3]=1

참가 물질

3

반응물 1

HCID 4263002-(3-Fluoro-4-methoxyphenyl)ethanamine

생성물 1

HCID 1932924-(2-Aminoethyl)-2-fluorophenol

시약·촉매·용매 1

HCID 260Hydrogen Bromide용매

실험 절차

Intermediate 82 was dissolved in 200 mL of 48% aqueous HBr and the mixture heated to reflux for 2 hours. The Solvent was removed by rotary evaporation. The residue was taken up in 100 mL of ethanol and the solvent again removed. This was repeated twice more to remove residual water. LC-MS showed the product was >90% pure had the expected M+H+ of 156.

후처리

  1. temperaturethe mixture heated
  2. temperatureto reflux for 2 hours
  3. customThe Solvent was removed by rotary evaporation
  4. customthe solvent again removed
  5. customto remove residual water

출처 및 근거

ORD 기록
ord-4035c7512b6c4308a9a4a02c4ef4de14
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08268822B2

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