Hydrochloric Acid → 1003320-03-3

HRID 238652

반응식

HRID 238652 반응식
[CH:1]([C:3]1[N:4]=[C:5]([CH:8]2[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]2)[S:6][CH:7]=1)=[O:2].[ClH:21].C(OCC)C>ClCCl>[ClH:21].[NH:11]1[CH2:10][CH2:9][CH:8]([C:5]2[S:6][CH:7]=[C:3]([CH:1]=[O:2])[N:4]=2)[CH2:13][CH2:12]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 7172298tert-Butyl 4-(4-formyl-1,3-thiazol-2-yl)piperidine-1-carboxylate

생성물 1

HCID 866312421003320-03-3

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 1,1-dimethylethyl 4-(4-formyl-2-thiazolyl)-1-piperidinecarboxylate (1.0 g, 3.4 mmol) in dichloromethane (20 mL) was added a solution of hydrogen chloride in diethyl ether (2.0 mL, 15 ml, 30 mmol). The reaction mixture was stirred under nitrogen at room temperature for 2 h and then evaporated under reduced pressure to give 1.2 g of the title compound as a white solid.

후처리

  1. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-031bd07804ce4d2d89ecdaf770b44a56
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08642634B2

연결된 노트

불러오는 중…