2H-1,4-Benzoxazin-3(4H)-one,4-methyl- → 6-[2-(4-Bromo-2-chloro-phenyl)-acetyl]-4-methyl-4H-benzo[1,4]oxazin-3-one

HRID 2386712노트

반응식

HRID 2386712 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=O)=[C:4]([Cl:12])[CH:3]=1.[CH3:13][N:14]1[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=2[O:17][CH2:16][C:15]1=[O:24].[Al+3].[Cl-].[Cl-].[Cl-]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([C:21]2[CH:22]=[CH:23][C:18]3[O:17][CH2:16][C:15](=[O:24])[N:14]([CH3:13])[C:19]=3[CH:20]=2)=[O:11])=[C:4]([Cl:12])[CH:3]=1

참가 물질

4

반응물 3

HCID 890322H-1,4-Benzoxazin-3(4H)-one,4-methyl-HCID 6451240Aluminum(III) ChlorideHCID 534036172-(4-Bromo-2-chlorophenyl)acetic acid

생성물 1

HCID 666973756-[2-(4-Bromo-2-chloro-phenyl)-acetyl]-4-methyl-4H-benzo[1,4]oxazin-3-one

실험 절차

In analogy to Example 1, step 1, (4-bromo-2-chloro-phenyl)-acetic acid was converted to the acid chloride and subsequently reacted with 4-methyl-2H-1,4-benzoxazin-3(4H)-one in the presence of AlCl3 to give the title compound as a light brown solid. MS (m/e, ISP neg. ion)=392.1 [M−H+].

출처 및 근거

ORD 기록
ord-ba333a086d404fc28cad94cca64d75d8
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08268820B2

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