Thiophenol → 5-Chloro-2-pyridinyl phenyl sulfide

반응식

Cl[C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][N:3]=1.[C:9]1([SH:15])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[C:9]1([S:15][C:2]2[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][N:3]=2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

참가 물질

반응물 2

HCID 7969Thiophenol

HCID 276852,5-Dichloropyridine

생성물 1

HCID 121330785-Chloro-2-pyridinyl phenyl sulfide수율 60.6%

실험 절차

2,5 Dichloropyridine (8.9 g, 60 mmol) and thiophenol (6.1 mL, 60 mmol) were heated to 150° C. for 41 h. The mixture then was removed from heat and cooled to room temperature. Column chromatography (silica gel, 200 mL) using hexanes as eluent gave 8.06 g of the title compound; IR (liq.) 1564, 1548, 1476, 1440, 1356, 1122, 1092, 1024, 1006, 821, 748, 727, 706, 691, 628 cm−1. 1H NMR (CDCl3) δ 6.8, 7.4, 7.6, 8.38.

후처리

customThe mixture then was removed
temperaturefrom heat

출처 및 근거

ORD 기록: ord-abb631e1a8394b2ab868383dd7c1e0d7
출처 데이터셋: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06855709B2

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