Sodium borohydride → (2-Amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)methanol
반응식
[NH2:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([CH:9]=[O:10])=[C:4]([NH:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[N:3]=1.[BH4-].[Na+]>CO>[NH2:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([CH2:9][OH:10])=[C:4]([NH:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[N:3]=1참가 물질
4
실험 절차
To the product from step (ii) (4 g) in MeOH (50 ml), sodium borohydride (0.7 g) was added portionwise over 5 min. The mixture was stirred at rt for 1 h then the solvent removed under reduced pressure. The residue was partitioned between EtOAc and water, the organics were separated, dried and evaporated under reduced pressure to give the subtitle compound, 3.89 g.
후처리
- customthe solvent removed under reduced pressure
- customThe residue was partitioned between EtOAc and water
- customthe organics were separated
- customdried
- customevaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-547146c5f8b049e9aa0a1eff84f3b9a2
- 출처 데이터셋
- uspto-grants-2012_09
- 특허 번호
- US08268990B2
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