Hydrochloric Acid → 2,2-Difluorocyclohexan-1-amine--hydrogen chloride (1/1)
반응식
[F:1][C:2]1([F:19])[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]1[NH:8]C(=O)OCC1C=CC=CC=1.[ClH:20]>>[ClH:20].[F:1][C:2]1([F:19])[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]1[NH2:8]참가 물질
3
실험 절차
A solution of benzyl 2,2-difluorocyclohexylcarbamate (38 mg, 0.14 mmol) in 6 N HCl (2 mL) was heated at 100° C. for 2 h. The cooled reaction mixture was extracted with ether (3×1 mL) and the combined organic layers were concentrated to give 2,2-difluorocyclohexanamine hydrochloride as a light brown solid (23 mg, 96% crude).
후처리
- customThe cooled reaction mixture
- extractionwas extracted with ether (3×1 mL)
- concentrationthe combined organic layers were concentrated
출처 및 근거
- ORD 기록
- ord-8529e6807ad34e4b954d681937bedc1c
- 출처 데이터셋
- uspto-grants-2014_02
- 특허 번호
- US08642576B2
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