Hydrochloric Acid → HCID 68643985, 화합물

HRID 2388670노트

반응식

HRID 2388670 반응식
[ClH:1].[OH:2][CH2:3][C@@H:4]1[CH2:13][CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]1C(OC(C)(C)C)=O>CO>[ClH:1].[NH:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[CH2:12][CH2:13][C@H:4]1[CH2:3][OH:2]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 57263166HCID 57263166, 화합물

생성물 1

HCID 68643985HCID 68643985, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Hydrogen chloride in methanol (1.25 mol/l, 60 ml) was added to (S)-tert-butyl 2-(hydroxymethyl)-3,4-dihydroquinoline-1(2H)-carboxylate (3.98 g, 15.1 mmol) and the mixture was refluxed for 2 h. The solvent was removed in vacuo, the residue was taken up in ethanol (5 ml) and the mixture was cooled. Diethylether (200 ml) was added and the mixture was stirred in an ice bath for 30 min. The precipitate was filtered out with suction, washed with diethylether and dried in vacuo.

후처리

  1. temperaturethe mixture was refluxed for 2 h
  2. customThe solvent was removed in vacuo
  3. temperaturethe mixture was cooled
  4. additionDiethylether (200 ml) was added
  5. filtrationThe precipitate was filtered out with suction
  6. washwashed with diethylether
  7. customdried in vacuo

출처 및 근거

ORD 기록
ord-05f1bd327e674993b3f39a04b1cb44bd
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08268814B2

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