Hydrochloric Acid → 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid hydrochloride

HRID 2388724노트

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HRID 2388724 반응식
[S:1]1[C:9]2[CH2:8][CH2:7][N:6](C(OCC)=O)[CH2:5][C:4]=2[CH:3]=[C:2]1[C:15]([O:17]CC)=[O:16].[ClH:20]>[OH-].[K+]>[ClH:20].[S:1]1[C:9]2[CH2:8][CH2:7][NH:6][CH2:5][C:4]=2[CH:3]=[C:2]1[C:15]([OH:17])=[O:16]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 14254905Diethyl 6,7-dihydrothieno[3,2-c]pyridine-2,5(4H)-dicarboxylate

생성물 1

HCID 686439894,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid hydrochloride수율 30%

시약·촉매·용매 1

HCID 14797Potassium Hydroxide용매

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온도
0 °C

실험 절차

A solution of diethyl 6,7-dihydrothieno[3,2-c]pyridine-2,5(4H)-dicarboxylate (1.76 mmol) in 3.5 N potassium hydroxide solution (3 ml) was heated under reflux for 3 hours. The course of the reaction was monitored by thin layer chromatography. The reaction mixture was then cooled to 0° C. and acidified with concentrated hydrochloric acid. The solid which had precipitated was filtered out and dried. The desired product was obtained in a yield of 30%.

후처리

  1. temperatureunder reflux for 3 hours
  2. customThe solid which had precipitated
  3. filtrationwas filtered out
  4. customdried

출처 및 근거

ORD 기록
ord-b0fd010fb3bc4f9ab792a02ae03db004
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08268814B2

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