Diethyl Ether → 2-[(1-Methoxymethoxy-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-amino]-2-methyl-propionic acid methyl ester

HRID 238897노트

반응식

HRID 238897 반응식
[CH3:1][O:2][CH2:3][O:4][C:5]1[C:14]2[CH2:13][CH2:12][CH2:11][CH2:10][C:9]=2[CH:8]=[CH:7][C:6]=1[C:15]([OH:17])=O.Cl.[CH3:19][O:20][C:21](=[O:26])[C:22]([NH2:25])([CH3:24])[CH3:23].C(N(CC)C(C)C)(C)C.C(OCC)C>CN(C)C=O.O>[CH3:19][O:20][C:21](=[O:26])[C:22]([NH:25][C:15]([C:6]1[CH:7]=[CH:8][C:9]2[CH2:10][CH2:11][CH2:12][CH2:13][C:14]=2[C:5]=1[O:4][CH2:3][O:2][CH3:1])=[O:17])([CH3:24])[CH3:23]

참가 물질

7

반응물 4

HCID 3283Diethyl EtherHCID 81531DiisopropylethylamineHCID 13258034Methyl 2-aminoisobutyrate hydrochlorideHCID 688443591-Methoxymethoxy-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid

생성물 1

HCID 688409232-[(1-Methoxymethoxy-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-amino]-2-methyl-propionic acid methyl ester수율 76.3%

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

In a round bottom flask was placed 0.96 g 1-methoxymethoxy-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid, 1.25 g 2-amino-2-methyl-propionic acid methyl ester hydrochloride, 3.09 g of O-(7-azabenzotriazole-1-yl)-N,N,N,N-tetramethyluronium hexafluoro phosphate and 2.83 ml of N,N-diisopropylethylamine in 60 ml of N,N-di-methylformamide. It was left stirring at room temperature overnight. 60 ml of diethylether and 60 ml of water were added to the reaction. The organic layer was separated and washed again with 50 ml of water. It was dried over magnesium sulphate, filtered and concentrated in vacuo to afford a crude yellow oil. Purification was performed by flash chromatography (silica, heptanes/ethyl acetate) to give 1.04 g 2-[(1-methoxymethoxy-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-amino]-2-methyl-propionic acid methyl ester.

후처리

  1. customIn a round bottom flask was placed
  2. waitIt was left
  3. customThe organic layer was separated
  4. washwashed again with 50 ml of water
  5. dry with materialIt was dried over magnesium sulphate
  6. filtrationfiltered
  7. concentrationconcentrated in vacuo
  8. customto afford a crude yellow oil
  9. customPurification

출처 및 근거

ORD 기록
ord-db2a7331d0d94b898a20155a54c3122b
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08642643B2

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