홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

1,2-Dichloroethane → n-(4-Chloro-3-quinoxalin-2-yl-phenyl)-4-methanesulfonyl-benzamide

HRID 2389260
노트
인쇄 미리보기

반응식

HRID 2389260 반응식
[CH3:1][S:2]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=O)=[CH:7][CH:6]=1)(=[O:4])=[O:3].[CH2:14]([Cl:17])[CH2:15]Cl.CCN(C(C)C)C(C)C.Cl[C:28]1[CH:29]=[C:30](O)[C:31]2[N:35]=N[NH:33][C:32]=2[CH:36]=1.[NH2:38][C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1>>[Cl:17][C:14]1[CH:15]=[CH:44][C:39]([NH:38][C:9](=[O:11])[C:8]2[CH:7]=[CH:6][C:5]([S:2]([CH3:1])(=[O:3])=[O:4])=[CH:13][CH:12]=2)=[CH:40][C:41]=1[C:42]1[CH:43]=[N:35][C:31]2[C:32](=[CH:36][CH:28]=[CH:29][CH:30]=2)[N:33]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 5

HCID 111,2-DichloroethaneHCID 6115AnilineHCID 77670p-(Methylsulphonyl)benzoic acidHCID 81531DiisopropylethylamineHCID 178516184HCID 178516184, 화합물

생성물 1

HCID 59826481n-(4-Chloro-3-quinoxalin-2-yl-phenyl)-4-methanesulfonyl-benzamide수율 52.2%

실험 절차

Procedure D was performed using 4-(methylsulfonyl)benzoic acid (102 mg, 0.49 mmol), EDC (186 mg, 0.93 mmol), DIPEA (0.16 ml, 0.93 mmol), 6-chloro-hydroxybenzotriazole (162 mg, 0.93 mmol) and aniline (119 mg, 0.46 mmol). The crude product was purified by flash column chromatography on silica gel eluting with EtOAc:hexanes (0:1 to 3:2) to afford the desired 4-chloro-3-quinoxalin-2-yl-phenylamine (104 mg, 0.24 mmol).

후처리

  1. customThe crude product was purified by flash column chromatography on silica gel eluting with EtOAc:hexanes (0:1 to 3:2)

출처 및 근거

ORD 기록
ord-1d0293db9972459ea0b5d7939f287d9c
출처 데이터셋
uspto-grants-2012_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08273743B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트