Hydrochloric Acid → HCID 66911325, 화합물
반응식
[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH2:10][NH:11]C(=O)OC(C)(C)C)[CH:5]=[CH:4][C:3]=1[C:19]#[N:20].[ClH:21]>O1CCOCC1>[ClH:21].[ClH:21].[NH2:1][C:2]1[C:3]([C:19]#[N:20])=[CH:4][CH:5]=[C:6]([NH:8][CH2:9][CH2:10][NH2:11])[N:7]=1참가 물질
4
실험 절차
6.76 g (24.38 mmol) of tert-butyl {2-[(6-amino-5-cyanopyridin-2-yl)amino]ethyl}carbamate (Example 110A) are dissolved in 122 ml of 4N hydrogen chloride in dioxane and stirred for 30 min. The reaction mixture is concentrated to one half, and an equal portion of diethyl ether is added. The reaction mixture is stirred for 20 min, and the product is filtered off and washed with diethyl ether. 5.43 g (89% of theory) of the product are obtained as a solid.
후처리
- concentrationThe reaction mixture is concentrated to one half
- additionan equal portion of diethyl ether is added
- stirringThe reaction mixture is stirred for 20 min
- filtrationthe product is filtered off
- washwashed with diethyl ether
- custom5.43 g (89% of theory) of the product are obtained as a solid
출처 및 근거
- ORD 기록
- ord-cf0ef50da7f343648cc34fd54a3c4f8f
- 출처 데이터셋
- uspto-grants-2012_09
- 특허 번호
- US08273752B2
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