Hydrochloric Acid → (3-Chloro-2-methylphenyl)methanol
반응식
[Cl:1][C:2]1[C:3]([CH3:11])=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5](O)=[O:6].Cl>C1COCC1>[Cl:1][C:2]1[C:3]([CH3:11])=[C:4]([CH:8]=[CH:9][CH:10]=1)[CH2:5][OH:6]참가 물질
4
실험 절차
To a solution of 1.70 g of 3-chloro-2-methylbenzoic acid in 20 mL of THF was added dropwise 20 mL of a borane/THF complex under ice-cooling, followed by stirring at room temperature for 2 hours. After completion of the reaction, 1 N hydrochloric acid was added to the reaction liquid, followed by extraction with chloroform. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate and then concentrated under reduced pressure to obtain 1.52 g (yield 97%) of a title compound as a white crystal.
후처리
- temperaturecooling
- additionwas added to the reaction liquid
- extractionfollowed by extraction with chloroform
- washThe organic layer was washed with saturated brine
- dry with materialdried over anhydrous sodium sulfate
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-f408fc813bcc47139652cd15c906a7da
- 출처 데이터셋
- uspto-grants-2012_09
- 특허 번호
- US08273766B2
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