Sodium hydride → 6-Bromo-2,3-dihydro-1lambda6-benzothiophene-1,1,3-trione

HRID 2390291노트

반응식

HRID 2390291 반응식
[Br:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8]C)=O)=[C:4]([S:12]([CH3:15])(=[O:14])=[O:13])[CH:3]=1.[H-].[Na+]>C1COCC1>[Br:1][C:2]1[CH:11]=[CH:10][C:5]2[C:6](=[O:8])[CH2:15][S:12](=[O:14])(=[O:13])[C:4]=2[CH:3]=1

참가 물질

4

반응물 2

HCID 24758Sodium hydrideHCID 53393139Methyl 4-bromo-2-(methylsulfonyl)benzoate2회

생성물 1

HCID 565941086-Bromo-2,3-dihydro-1lambda6-benzothiophene-1,1,3-trione수율 102.2%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of methyl 4-bromo-2-(methylsulfonyl)benzoate (Intermediate 239; 4.00 g; 13.6 mmol) in anhydrous THF (60 ml) was treated with NaH (595 mg; 13.6 mmol) and stirred at RT for 1.5 h. The reaction was quenched with water. AcOEt and a 1N solution of HCl in water were added and the phases were separated. The organic phase was washed with brine, dried on MgSO4, filtered and concentrated to give the title compound as a yellow solid (3.63 g).

후처리

  1. customThe reaction was quenched with water
  2. additionAcOEt and a 1N solution of HCl in water were added
  3. customthe phases were separated
  4. washThe organic phase was washed with brine
  5. customdried on MgSO4
  6. filtrationfiltered
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-fd212ac934024d2488fbe2f4e26a52e1
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08273769B2

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