Acetone → Methyl 3-methoxy-5-methylbenzoate

반응식

[OH:1][C:2]1C=C(C=C(C)C=1)C(O)=O.[C:12](=[O:15])([O-])[O-:13].[K+].[K+].[CH3:18]I.CN([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25]N=1)C.[CH3:29][C:30](C)=O>>[CH3:2][O:1][C:26]1[CH:27]=[C:28]([CH:23]=[C:29]([CH3:30])[CH:25]=1)[C:12]([O:13][CH3:18])=[O:15]

참가 물질

반응물 5

HCID 180Acetone

HCID 6328Methyl iodide

HCID 11430Potassium Carbonate

HCID 218852-Dimethylaminopyridine

HCID 2317563-Hydroxy-5-methylbenzoic acid

생성물 1

HCID 13834966Methyl 3-methoxy-5-methylbenzoate수율 93.5%

실험 절차

To acetone (180 mL) were added 3-hydroxy-5-methylbenzoic acid (9 g, 59.16 mmol), potassium carbonate (33 g, 237 mmol) and methyl iodide (37.2 mL, 591.6 mmol). For O-methylation, the resulting mixture was heated at 65° C. for 12 hours in the presence of a catalytic amount of dimethylaminopyridine. After vacuum distillation of the acetone, the concentrate was treated in water (300 mL) and dichloromethane (450 mL). The organic layer was dried over anhydrous magnesium sulfate and subjected to distillation. Column chromatography (silica gel, ethyl acetate-hexane 1:12 v/v) with the residue produced the title compound as a colorless liquid (9.98 g, 93.5%).