N-bromobutanimide → (2-Bromo-4-tert-butyl-5-methoxy-phenyl)-methanol

HRID 2390861노트

반응식

HRID 2390861 반응식
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][OH:12])=[CH:7][C:6]=1[O:13][CH3:14])([CH3:4])([CH3:3])[CH3:2].C1C(=O)N([Br:22])C(=O)C1>C(Cl)(Cl)(Cl)Cl.OS([O-])=O.[Na+]>[Br:22][C:9]1[CH:10]=[C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])[C:6]([O:13][CH3:14])=[CH:7][C:8]=1[CH2:11][OH:12]

참가 물질

5

반응물 2

HCID 67184N-bromobutanimideHCID 534014571206775-43-0

생성물 1

HCID 67070042(2-Bromo-4-tert-butyl-5-methoxy-phenyl)-methanol수율 100%

시약·촉매·용매 2

HCID 5943Carbon Tetrachloride용매HCID 23665763Sodium Bisulfite용매

실험 절차

step b—To a solution of 345 (2.08 g, 10.70 mmol) in CCl4 (75 mL) was added NBS (2.10 g, 11.80 mmol). The reaction was stirred for 15 min then diluted with a cold 10% aqueous NaHSO3. The reaction mixture was extracted with DCM. The organic extract was washed with brine, dried (MgSO4), filtered and concentrated. The residue was taken up in hexanes (80 mL) and then concentrated to afford 2.9 g (100%) of 344a as a white solid.

후처리

  1. extractionThe reaction mixture was extracted with DCM
  2. extractionThe organic extract
  3. washwas washed with brine
  4. dry with materialdried (MgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-1e744d1e0f6d4be5a7ac2ddaf8c8ce87
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08273773B2

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