L-Tartaric acid → (1R,2S,3R,5R,6R)-2-amino-2-cyano-3-[(3,4-dichloro benzyl)oxy]-6-fluoro bicyclo[3.1.0]hexane-6-carboxamide L-tartarate

To ethyl acetate (5 mL) solution containing 250.2 mg of the mixture of (1R,2S,3R,5R,6R)-2-amino-2-cyano-3-[(3,4-dichloro benzyl)oxy]-6-fluoro bicyclo[3.1.0]hexane-6-carboxamide (6a) and (1R,2R,3R,5R,6R)-2-amino-2-cyano-3-[(3,4-dichloro benzyl)oxy]-6-fluoro bicyclo[3.1.0]hexane-6-carboxamide (8a) [containing (6a): 168.6 mg and (8a): 74.8 mg], 107.9 mg (content: 99 wt %) of L-tartaric acid was added and stirred for 19 hrs and 15 min at room temperature. The resulting slurry was filtered under suction, washed with 2 mL of ethyl acetate, and dried under reduced pressure at room temperature. 254.6 mg of the resulting colorless powder (265.9 mg obtained) was suspended in 2.5 mL of ethyl acetate, and stirred at room temperature for 15.5 hrs. The resulting slurry was filtered under suction, washed with 2 mL of ethyl acetate, and dried under reduced pressure at room temperature to obtain 206.9 mg of (1R,2S,3R,5R,6R)-2-amino-2-cyano-3-[(3,4-dichloro benzyl)oxy]-6-fluoro bicyclo[3.1.0]hexane-6-carboxamide L-tartarate (6c) as a colorless solid.

1. additionwas added
2. filtrationThe resulting slurry was filtered under suction
3. washwashed with 2 mL of ethyl acetate
4. customdried under reduced pressure at room temperature
5. stirringstirred at room temperature for 15.5 hrs
6. filtrationThe resulting slurry was filtered under suction
7. washwashed with 2 mL of ethyl acetate
8. customdried under reduced pressure at room temperature

ORD 기록

ord-7420fd1ed9f341bc980b528f802d42ac

출처 데이터셋

uspto-grants-2014_02

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08642777B2