Azobisisobutyronitrile → HCID 86611703, 화합물
반응식
CC(N=NC(C#N)(C)C)(C#N)C.[Cl:13][C:14]1[N:19]=[C:18]2[S:20][N:21]=[C:22]([CH3:23])[C:17]2=[CH:16][CH:15]=1.[Br:24]NC(=O)CCC(N)=O>C(Cl)(Cl)(Cl)Cl>[Br:24][CH2:23][C:22]1[C:17]2[C:18](=[N:19][C:14]([Cl:13])=[CH:15][CH:16]=2)[S:20][N:21]=1참가 물질
5
반응 조건
- 온도
- 80 °C
실험 절차
AIBN (1.35 mmol) was added to a solution of 6-chloro-3-methylisothiazolo[5,4-b]pyridine (13.5 mmol) and N-bromosuccinamide (27.1 mmol) in carbon tetrachloride (25 mL). The reaction mixture was heated at 80° C. for 6 h, allowed to cool to rt, and the precipitated solids were removed by filtration. The filtrate was concentrated to provide crude 3-(bromomethyl)-6-chloroisothiazolo[5,4-b]pyridine as yellow oil.
후처리
- temperatureto cool to rt
- customthe precipitated solids were removed by filtration
- concentrationThe filtrate was concentrated
출처 및 근거
- ORD 기록
- ord-7be6d95886c14e828c3202c504564f44
- 출처 데이터셋
- uspto-grants-2012_09
- 특허 번호
- US08273891B2
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