4-Piperidinecarboxamide → 1-Benzylpiperidine-4-carboxamide

HRID 239105

반응식

HRID 239105 반응식
[CH2:1](Cl)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:9]1[CH2:14][CH2:13][CH:12]([C:15]([NH2:17])=[O:16])[CH2:11][CH2:10]1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH2:1]([N:9]1[CH2:14][CH2:13][CH:12]([C:15]([NH2:17])=[O:16])[CH2:11][CH2:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 37724-PiperidinecarboxamideHCID 7503Benzyl ChlorideHCID 11430Potassium Carbonate

생성물 1

HCID 7831561-Benzylpiperidine-4-carboxamide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

10.2 mL benzylchloride was added to 10 g piperidine-4-carboxylic acid amide and 21.6 g potassiumcarbonate in 280 mL DMF at 5° C. The reaction was stirred over night at RT. The solvent was removed and the residue was dissolved in water and dichlormethane. The organic layer was separated and evaporated. The residue was purified by column chromatographie (silica gel, eluent: dichlormethane/methanol 95:5 to 90:10) to give 9.8 g of the desired product.

후처리

  1. customThe solvent was removed
  2. dissolutionthe residue was dissolved in water
  3. customThe organic layer was separated
  4. customevaporated
  5. customThe residue was purified by column chromatographie (silica gel, eluent: dichlormethane/methanol 95:5 to 90:10)

출처 및 근거

ORD 기록
ord-d51ef4104a7f48138255f28aebcc2c3c
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08642774B2

연결된 노트

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