Water → 1-(4'-Acetylbiphenyl-4-yl)cyclopropanecarboxylic acid isopropyl ester

HRID 2391051노트

반응식

HRID 2391051 반응식
[CH:1]([O:4][C:5]([C:7]1([C:10]2[CH:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:12][CH:11]=2)[CH2:9][CH2:8]1)=[O:6])([CH3:3])[CH3:2].[Cl-].[Al+3].[Cl-].[Cl-].[C:26](Cl)(=[O:28])[CH3:27].O>C(Cl)Cl>[CH:1]([O:4][C:5]([C:7]1([C:10]2[CH:11]=[CH:12][C:13]([C:16]3[CH:21]=[CH:20][C:19]([C:26](=[O:28])[CH3:27])=[CH:18][CH:17]=3)=[CH:14][CH:15]=2)[CH2:9][CH2:8]1)=[O:6])([CH3:3])[CH3:2]

참가 물질

6

반응물 4

HCID 962WaterHCID 6367Acetyl chlorideHCID 6451240Aluminum(III) ChlorideHCID 666602081-(Biphenyl-4-yl)cyclopropanecarboxylic acid isopropyl ester

생성물 1

HCID 666602881-(4'-Acetylbiphenyl-4-yl)cyclopropanecarboxylic acid isopropyl ester수율 108.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To 1-(biphenyl-4-yl)cyclopropanecarboxylic acid isopropyl ester (10.2 g, 36 mmol) in CH2Cl2 (100 mL) was added aluminum chloride (10.2 g, 76.5 mmol) followed by acetyl chloride (5.97 g, 76.5 mmol). The solution was stirred at room temperature for 1.5 hours then slowly poured into water. The organic layer was separated and extracted 1 time with sodium potassium tartrate solution (20 g in 250 mL water). The organic layer was dried and evaporated to yield 12.6 g of the title compound.

후처리

  1. customThe organic layer was separated
  2. extractionextracted 1 time with sodium potassium tartrate solution (20 g in 250 mL water)
  3. customThe organic layer was dried
  4. customevaporated

출처 및 근거

ORD 기록
ord-64a862f4c3a142938e97e3244ed2198c
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08273780B2

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