4-(Trifluoromethyl)phenol → 2-Hydroxy-5-trifluoromethylbenzaldehyde

HRID 23914

반응식

HRID 23914 반응식
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][CH:4]=1.[C:12](OCC)(=[O:14])C.CCCCCC>>[OH:9][C:6]1[CH:5]=[CH:4][C:3]([C:2]([F:10])([F:11])[F:1])=[CH:8][C:7]=1[CH:12]=[O:14]

참가 물질

3

반응물 2

HCID 678744-(Trifluoromethyl)phenolHCID 21226206Ethyl acetate hexane

생성물 1

HCID 155009882-Hydroxy-5-trifluoromethylbenzaldehyde수율 34%

실험 절차

Following the general procedure and FCC purification with 30% ethyl acetate-hexane, 4-trifluoromethyl phenol (10.0 g, 61.7 mmol) gave 2-hydroxy-5-trifluoromethyl-benzaldehyde 27 (3.9 g, 34%) as a pink solid.

출처 및 근거

ORD 기록
ord-28e0930bac704493b0adc4c206e0474c
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855695B2

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