Water → 1-(4-Nitrophenyl)-1H-1,2,4-triazole
반응식
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.[NH:11]1[CH:15]=[N:14][CH:13]=[N:12]1.C(=O)([O-])[O-].[K+].[K+].O>CS(C)=O>[N:11]1([C:2]2[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=2)[CH:15]=[N:14][CH:13]=[N:12]1참가 물질
6
반응 조건
- 온도
- 90 °C
실험 절차
4Fluoronitrobenzene (2 g, 0.014 mol), 1,2,4-triazole (1 g, 0.014 mol), potassium carbonate (1.96 g, 0.014 mol) were dissolved in DMSO (50 ml) and stirred at 90° C. for 24 h under dry conditions. The yellow suspension was poured into water (150 ml), extracted (EtOAc), dried (Na2SO4) and evaporated under reduced pressure to afford an orange solid which was purified by flash column chromatography on silica eluting with n-pentane/ethyl acetate (50-100%) to afford a white solid (2.57 g 97%).
후처리
- extractionextracted (EtOAc)
- dry with materialdried (Na2SO4)
- customevaporated under reduced pressure
- customto afford an orange solid which
- customwas purified by flash column chromatography on silica eluting with n-pentane/ethyl acetate (50-100%)
- customto afford a white solid (2.57 g 97%)
출처 및 근거
- ORD 기록
- ord-a98078005de946f7bbb9ee7c31a04b54
- 출처 데이터셋
- uspto-grants-1998_09
- 특허 번호
- US05801170
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