Hydrochloric Acid → Methyl (R)-2-(4-hydroxyphenoxy)propionate

반응식

C([O:4][C:5]1[CH:17]=[CH:16][C:8]([O:9][C@H:10]([CH3:15])[C:11]([O:13][CH3:14])=[O:12])=[CH:7][CH:6]=1)(=O)C.Cl>CO>[OH:4][C:5]1[CH:6]=[CH:7][C:8]([O:9][C@H:10]([CH3:15])[C:11]([O:13][CH3:14])=[O:12])=[CH:16][CH:17]=1

참가 물질

실험 절차

A mixture of 45 g (189 mmol) of methyl (R)-2-(4-acetoxyphenoxy)propionate (enantiomeric excess 94-95%), 135 ml of methanol and 2.5 ml of methanol saturated with gaseous hydrogen chloride was refluxed for 5 h and subsequently concentrated. The crude product was purified by distillation at 140° C. under 0.1 mbar. Yield: 96% (94-95% enantiomeric excess).

후처리

temperaturewas refluxed for 5 h
concentrationsubsequently concentrated
distillationThe crude product was purified by distillation at 140° C. under 0.1 mbar

출처 및 근거

ORD 기록: ord-221fdf92b5cc45bd9fbc54f9021c4ee5
출처 데이터셋: uspto-grants-1998_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05801272

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참가 물질

반응물 2

HCID 313Hydrochloric Acid

HCID 54186344Methyl (R)-2-(4-acetoxyphenoxy)propionate

생성물 1

HCID 2733752Methyl (R)-2-(4-hydroxyphenoxy)propionate수율 96%

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

후처리

temperaturewas refluxed for 5 h
concentrationsubsequently concentrated
distillationThe crude product was purified by distillation at 140° C. under 0.1 mbar

출처 및 근거

ORD 기록: ord-221fdf92b5cc45bd9fbc54f9021c4ee5
출처 데이터셋: uspto-grants-1998_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05801272

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