3-Fluoro-4-methylaniline → 3-Fluoro-4-methylphenyl methyl sulfide

HRID 2393039

반응식

HRID 2393039 반응식
N(OC(C)(C)C)=O.[F:8][C:9]1[CH:10]=[C:11]([CH:13]=[CH:14][C:15]=1[CH3:16])N.[CH3:17][S:18]SC>C(Cl)(Cl)Cl>[F:8][C:9]1[CH:10]=[C:11]([S:18][CH3:17])[CH:13]=[CH:14][C:15]=1[CH3:16]

참가 물질

5

반응물 3

HCID 99573-Fluoro-4-methylaniline2회HCID 10906Tert-Butyl nitrite2회HCID 12232Dimethyl Disulfide

생성물 1

HCID 534144923-Fluoro-4-methylphenyl methyl sulfide

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

t-Butyl nitrite (4 ml) was added to a mixture of 3-fluoro-4-methylaniline (5 g) and dimethyldisulphide (36 ml) in chloroform. After the reaction had initiated t-butyl nitrite (22 ml) and a solution of 3-fluoro-4-methylaniline (20.0 g) in chloroform were added simultaneously. The mixture was then stirred at room temperature for 2 hours. The mixture was washed with water, hydrochloric acid (2M), water, dried (MgSO4) and filtered. The filtrate was evaporated to dryness to give 2-fluoro-4-(methylsulphenyl)toluene (25.37 g) as a red oil which was not further purified.

후처리

  1. washThe mixture was washed with water, hydrochloric acid (2M), water
  2. dry with materialdried (MgSO4)
  3. filtrationfiltered
  4. customThe filtrate was evaporated to dryness

출처 및 근거

ORD 기록
ord-71c25232191642829750fad44fcb71ff
출처 데이터셋
uspto-grants-1998_09
특허 번호
US05804532

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