Diazomethane → Methyl 8-Hydroxyquinoline-2-Carboxylate

HRID 2393091노트

반응식

HRID 2393091 반응식
[OH:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([C:12]([OH:14])=[O:13])[CH:8]=[CH:7]2.[N+](=[CH2:17])=[N-]>O1CCCC1>[OH:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([C:12]([O:14][CH3:17])=[O:13])[CH:8]=[CH:7]2

참가 물질

4

반응물 2

HCID 9550DiazomethaneHCID 740798-Hydroxyquinaldic acid

생성물 1

HCID 12336161Methyl 8-Hydroxyquinoline-2-Carboxylate수율 71.6%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

8-Hydroxyquinoline-2-carboxylic acid (2.08 g) and tetrahydrofuran (200 ml) were combined and stirred with ice bath cooling. Diazomethane (approx. 16.6 mmol in solution in diethyl ether) was then added and the whole stirred for 1.5 h as it slowly warmed to room temperature. Nitrogen was blown through the reaction mixture to purge any excess diazomethane and the solution was evaporated in vacuo to give the title compound (1.6 g).

후처리

  1. temperaturecooling
  2. stirringthe whole stirred for 1.5 h as it
  3. customto purge any excess diazomethane
  4. customthe solution was evaporated in vacuo

출처 및 근거

ORD 기록
ord-4c7b361eae324ebeabfcce85d7c21218
출처 데이터셋
uspto-grants-1998_09
특허 번호
US05804588

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