Methyl iodide → Methyl 8-methoxyquinoline-2-carboxylate

HRID 2393092노트

반응식

HRID 2393092 반응식
[OH:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([C:12]([O:14][CH3:15])=[O:13])[CH:8]=[CH:7]2.[C:16](=O)([O-])[O-].[K+].[K+].IC>CC(C)=O>[CH3:16][O:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([C:12]([O:14][CH3:15])=[O:13])[CH:8]=[CH:7]2

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 12336161Methyl 8-Hydroxyquinoline-2-Carboxylate

생성물 1

HCID 12336162Methyl 8-methoxyquinoline-2-carboxylate수율 100.6%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

Methyl 8-hydroxyquinoline-2-carboxylate (1.6 g), acetone (15 ml), potassium carbonate (1.3 g) and iodomethane (0.6 ml) were combined and stirred at room temperature for 48 h. The solvents were removed in vacuo and the resulting white residue suspended in water (25 ml) which was extracted with ethyl acetate (3×25 ml). The combined organic layers were dried (magnesium sulphate) and the solvents removed in vacuo to give the title compound as a white solid (1.72 g).

후처리

  1. customThe solvents were removed in vacuo
  2. extractionwas extracted with ethyl acetate (3×25 ml)
  3. dry with materialThe combined organic layers were dried (magnesium sulphate)
  4. customthe solvents removed in vacuo

출처 및 근거

ORD 기록
ord-374e71d9df9844cc84c39716c23cd704
출처 데이터셋
uspto-grants-1998_09
특허 번호
US05804588

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