Tetrahydrofuran → 2-Quinolinecarboxylic acid, 5-bromo-8-methoxy-

HRID 2393093노트

반응식

HRID 2393093 반응식
[Br:1][C:2]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([C:14]([O:16]C)=[O:15])=[N:7]2.O1CCCC1.O.[OH-].[Li+]>O>[Br:1][C:2]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([C:14]([OH:16])=[O:15])=[N:7]2

참가 물질

5

반응물 3

HCID 8028TetrahydrofuranHCID 168937Lithium hydroxide, monohydrateHCID 9900802HCID 9900802, 화합물

생성물 1

HCID 99436352-Quinolinecarboxylic acid, 5-bromo-8-methoxy-수율 0.9%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Methyl 5-bromo-8-methoxyquinoline-2-carboxylate (154 g), tetrahydrofuran (40 ml), water (40 ml) and lithium hydroxide monohydrate (0.436 g) were combined and stirred at room temperature for 1.5 h. The tetrahydrofuran was removed in vacuo and the resulting aqueous mixture was acidified with hydrochloric acid. The resulting white precipitate was collected by filtration and dried in vacuo to give the title compound (1.33 g) as a white solid.

후처리

  1. customThe tetrahydrofuran was removed in vacuo
  2. filtrationThe resulting white precipitate was collected by filtration
  3. customdried in vacuo

출처 및 근거

ORD 기록
ord-1c10f43d65074e3585a16ba9b4f4a23f
출처 데이터셋
uspto-grants-1998_09
특허 번호
US05804588

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