tert-Butanol → HCID 18979069, 화합물

HRID 2393094노트

반응식

HRID 2393094 반응식
[Br:1][C:2]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6](C(O)=O)=[N:7]2.[C:17]([OH:21])([CH3:20])([CH3:19])[CH3:18].C1(P(N=[N+]=[N-])(C2C=CC=CC=2)=[O:29])C=CC=CC=1.C([N:41]([CH2:44]C)CC)C>>[Br:1][C:2]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([NH:41][C:44]([O:21][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:29])=[N:7]2

참가 물질

5

반응물 4

HCID 6386tert-ButanolHCID 8471TriethylamineHCID 199401P,P-Diphenylphosphinic azideHCID 99436352-Quinolinecarboxylic acid, 5-bromo-8-methoxy-

생성물 1

HCID 18979069HCID 18979069, 화합물

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온도
80 °C

실험 절차

5-Bromo-8-methoxyquinoline-2-carboxylic acid (2 g), t-butanol (25 ml) and triethylamine (1.48 ml) were combined under a nitrogen atmosphere and heated to 80° C. Diphenylphosphorylazide (2.29 ml) was added to the solution and heating was continued for 60 h by which time a white preciptate was present. The reaction mixture was evaporated in vacuo onto silica and purified by flash chromatography to give the title compound (1.21 g) as an off white solid.

후처리

  1. temperatureheating
  2. customThe reaction mixture was evaporated in vacuo onto silica
  3. custompurified by flash chromatography

출처 및 근거

ORD 기록
ord-8fd8d820442340eda5fdae2f56b55428
출처 데이터셋
uspto-grants-1998_09
특허 번호
US05804588

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