Acrylamide → Phenidone

HRID 2393342노트

반응식

HRID 2393342 반응식
[C:1]1([NH:7][NH2:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:9](N)(=[O:12])[CH:10]=[CH2:11].[OH-].[K+]>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC>[C:1]1([N:7]2[CH2:11][CH2:10][C:9](=[O:12])[NH:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 6579AcrylamideHCID 7516PhenylhydrazineHCID 14797Potassium Hydroxide

생성물 1

HCID 7090Phenidone

시약·촉매·용매 1

HCID 74236Tetrabutylammonium Bromide촉매

실험 절차

Phenylhydrazine (10.8 g, 0.1 mol), and acrylamide (7.8 g, 0.11 mol), pulverized potassium hydroxide (12.5 g, 0.22) and a catalytic amount of tetrabutylammonium bromide is refluxed for 30 minutes. The precipitate is filtered and washed with toluene. The crystalline sold is dissolved in water. Acidification with acetic acid, filtration and drying gives 1-phenyl-3-pyrazolidone.

후처리

  1. filtrationThe precipitate is filtered
  2. washwashed with toluene
  3. dissolutionThe crystalline sold is dissolved in water
  4. filtrationAcidification with acetic acid, filtration
  5. customdrying

출처 및 근거

ORD 기록
ord-a82caac1fad34dcb8cdc22597bbf516d
출처 데이터셋
uspto-grants-1998_09
특허 번호
US05807863

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