Sodium Hydroxide → 5,5-Dimethoxypentanoic acid

HRID 2393687노트

반응식

HRID 2393687 반응식
[CH3:1][O:2][CH:3]([O:11][CH3:12])[CH2:4][CH2:5][CH2:6][C:7]([O:9]C)=[O:8].[OH-].[Na+]>CO>[CH3:12][O:11][CH:3]([O:2][CH3:1])[CH2:4][CH2:5][CH2:6][C:7]([OH:9])=[O:8]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 551444Methyl 5,5-dimethoxyvalerate

생성물 1

HCID 118050725,5-Dimethoxypentanoic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

12 mmoles methyl 5,5-dimethoxypentanoate (Stevens, R. V. et al., J Am Chem Soc (1979) 7054) were dissolved in 20 ml 50% aqueous methanol. 16 mmoles NaOH were added and the mixture was stirred for 2 hr at room temperature. The solvent was then evaporated, the residue layered with 30 ml EtOAc, and the sodium salt neutralized with ice-cold 1N HCl. The aqueous phase was extracted with an additional 20 ml EtOAc, the organic extracts combined and dried over K2CO3. The product was filtered and the solvent evaporated to provide 5,5-dimethoxypentanoic acid.

후처리

  1. customThe solvent was then evaporated
  2. extractionThe aqueous phase was extracted with an additional 20 ml EtOAc
  3. dry with materialdried over K2CO3
  4. filtrationThe product was filtered
  5. customthe solvent evaporated

출처 및 근거

ORD 기록
ord-f0f9e1b9ecc04f6c96d765e11669395d
출처 데이터셋
uspto-grants-1998_09
특허 번호
US05807979

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